Myrtle Beach is located on the northern South Carolina coast, where Highways 17 and 501 join. Known by many as the "Grand Strand", it includes the coastal area from the North Carolina state line at Little River to Pawleys Island south. And includes North Myrtle Beach. Myrtle Beach is about halfway between Wilmington, NC and Charleston, SC.

The area is served by Myrtle Beach International Airport (MYR). The closest Amtrak station is in Florence, SC, and the entire Grand Strand is served by Greyhound bus service.